Pestilence Spiritborn Endgame Build Guide
Last Updated: Jun 30, 2025 by Community Build
About
This is essentially an Aura-build using poisons that spread across the map as we move through our enemies as quickly as possible. By stacking Maximum Resource and Ferocity, the build achieves a very fast movement ability with Rushing Claw and extremely good survivability for higher Torments.
Gameplay Loop and Rotation
The Spiritborn build's rotation is about front-loading your powerful utility skills to gain maximum defensive and offensive buffs, and then aggressively spamming your core damage skill while these buffs are active.
Initiate your Buffs: Begin combat by casting all of your skills, including your Ultimate - building all the poison around you as your prepare to charge through the map.
Apply Damage Multiplier: Ensure your Scourge passive is active (or that enemies are CC'd) to apply the crucial damage multiplier.
Execute: Once all buffs are active, aggressively spam Rushing Claw. The skill should reset easily as long as you maintain your Ferociety stacks which we get from kills, CC and the passives.
Maintain your Skill Uptime: Repeat all of your skills on cooldown, not spamming them but keep them activate as needed.
Skills
Unique Gear
Additional information
Harmony of Ebewaka (Helm): Multiplies your damage based on your Spirit Hall choices and makes your poisons benefit from multiple Spirit type bonuses.
Ring of the Writhing Moon: Summons Poison Orbs that orbit around us, helping to make enemies vulnerable.
Skill Tree and Talisman
Spiritborn Basic Cluster
Vortex: This skill is casted automatically.
Ravager, Toxic Skin, Scourge, Counter-attack: Trigger these as needed to keep your buffs going.
Rushing Claw: Our movement ability and cooldown extender, you should be able to spam the skill as long as you have Ferocity stacks constantly refilling.
The Devourer: This is key for executing enemies as the poison builds up pasted their life pool - do not spam it but keep its effect on you.
Spiritborn Basic Cluster
Vortex: This skill is casted automatically.
Ravager, Toxic Skin, Scourge, Counter-attack: Trigger these as needed to keep your buffs going.
Rushing Claw: Our movement ability and cooldown extender, you should be able to spam the skill as long as you have Ferocity stacks constantly refilling.
The Devourer: This is key for executing enemies as the poison builds up pasted their life pool - do not spam it but keep its effect on you.
(Click on the image to expand it)Paragon Board
Spiritborn Starting Board
The Headhunter Glyph is inserted into this board.
Spiritborn Starting Board
The Headhunter Glyph is inserted into this board.
(Click on the image to expand it)Main Mercenary
Support Mercenary
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FAQ
Here are some of the most frequently asked questions for this guide:
Does this build have a downloadable Loot filter?
Diablo 4 will be getting a new Loot filter system with the newest expansion "Lord of Hatred" coming April 28th 2026.
For more information visit the expansion page.
Is there a Leveling guide for this build?
We have a beginners leveling guide for this class available - it helps to introduce the class, but is not a 1 - 70 leveling guide.
Where does this build rank in the tier list?
This build is ranked as an A-tier build overall.
